Drug interactions
Paclitaxel + Pentobarbital
Severity: Moderate
Paclitaxel and Pentobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce CYP3A4 and CYP2C enzymes and could lower paclitaxel exposure. This may reduce antitumor effect, though specific data for pentobarbital are lacking.
What this interaction means in plain words
Paclitaxel and Pentobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pentobarbital induces hepatic CYP3A4 and CYP2C8, increasing paclitaxel metabolism.
What to do
Avoid prolonged concurrent use when alternatives exist; otherwise monitor for reduced paclitaxel efficacy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Paclitaxel and Pentobarbital, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Paclitaxel
Frequently asked questions
Can I take Paclitaxel with Pentobarbital?
MediHelp rates the interaction as moderate. Paclitaxel and Pentobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates induce CYP3A4 and CYP2C enzymes and could lower paclitaxel exposure. This may reduce antitumor effect, though specific data for pentobarbital are lacking.
How serious is the interaction between Paclitaxel and Pentobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid prolonged concurrent use when alternatives exist; otherwise monitor for reduced paclitaxel efficacy.
What other medicines interact with Paclitaxel?
MediHelp also lists interactions of Paclitaxel with, for example, Adenovirus types 4 and 7 live, Cobicistat, Cyclosporine. The full list is on the Paclitaxel page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
