Drug interactions
Paclitaxel + Phenobarbital
Severity: Moderate
Paclitaxel and Phenobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenobarbital induces CYP2C8, CYP3A4 and P-glycoprotein, which may reduce paclitaxel exposure and potentially efficacy. Concurrent anticonvulsant use has been associated with altered paclitaxel clearance.
What this interaction means in plain words
Paclitaxel and Phenobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Enzyme and transporter induction by phenobarbital increases paclitaxel clearance.
What to do
Use a non-inducing antiseizure drug such as levetiracetam when possible; otherwise monitor tumor response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paclitaxel
Frequently asked questions
Can I take Paclitaxel with Phenobarbital?
MediHelp rates the interaction as moderate. Paclitaxel and Phenobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenobarbital induces CYP2C8, CYP3A4 and P-glycoprotein, which may reduce paclitaxel exposure and potentially efficacy. Concurrent anticonvulsant use has been associated with altered paclitaxel clearance.
How serious is the interaction between Paclitaxel and Phenobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-inducing antiseizure drug such as levetiracetam when possible; otherwise monitor tumor response.
What other medicines interact with Paclitaxel?
MediHelp also lists interactions of Paclitaxel with, for example, Adenovirus types 4 and 7 live, Cobicistat, Cyclosporine. The full list is on the Paclitaxel page.
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