Drug interactions
Paclitaxel + Quercetin
Severity: Minor
Paclitaxel and Quercetin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quercetin is a flavonoid supplement that affects P-glycoprotein and CYP enzymes, with inconsistent effects on paclitaxel exposure in experimental data. Clinical significance is unclear.
What this interaction means in plain words
Paclitaxel and Quercetin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Variable modulation of P-glycoprotein and CYP activity by quercetin; the net effect on paclitaxel is not well established.
What to do
Advise patients to avoid high-dose quercetin supplements during paclitaxel therapy and monitor response and toxicity.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Paclitaxel
Frequently asked questions
Can I take Paclitaxel with Quercetin?
MediHelp rates the interaction as minor. Paclitaxel and Quercetin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Quercetin is a flavonoid supplement that affects P-glycoprotein and CYP enzymes, with inconsistent effects on paclitaxel exposure in experimental data. Clinical significance is unclear.
How serious is the interaction between Paclitaxel and Quercetin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid high-dose quercetin supplements during paclitaxel therapy and monitor response and toxicity.
What other medicines interact with Paclitaxel?
MediHelp also lists interactions of Paclitaxel with, for example, Adenovirus types 4 and 7 live, Cobicistat, Cyclosporine. The full list is on the Paclitaxel page.
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