Drug interactions
Paclitaxel + Quinupristin / dalfopristin
Severity: Moderate
Paclitaxel and Quinupristin / dalfopristin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinupristin/dalfopristin inhibits CYP3A4 and could increase paclitaxel exposure. The effect is predicted rather than documented, and courses are usually short.
What this interaction means in plain words
Paclitaxel and Quinupristin / dalfopristin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Quinupristin/dalfopristin inhibits CYP3A4, reducing paclitaxel metabolism.
What to do
Monitor for paclitaxel toxicity such as neutropenia and neuropathy during the antibiotic course and consider an alternative antibiotic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paclitaxel
Frequently asked questions
Can I take Paclitaxel with Quinupristin / dalfopristin?
MediHelp rates the interaction as moderate. Paclitaxel and Quinupristin / dalfopristin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinupristin/dalfopristin inhibits CYP3A4 and could increase paclitaxel exposure. The effect is predicted rather than documented, and courses are usually short.
How serious is the interaction between Paclitaxel and Quinupristin / dalfopristin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for paclitaxel toxicity such as neutropenia and neuropathy during the antibiotic course and consider an alternative antibiotic.
What other medicines interact with Paclitaxel?
MediHelp also lists interactions of Paclitaxel with, for example, Adenovirus types 4 and 7 live, Cobicistat, Cyclosporine. The full list is on the Paclitaxel page.
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