Drug interactions
Paclitaxel + Rifampin
Severity: Major
Paclitaxel and Rifampin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampin strongly induces CYP2C8, CYP3A4 and P-glycoprotein, which can substantially reduce paclitaxel exposure and may compromise efficacy.
What this interaction means in plain words
Paclitaxel and Rifampin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Induction of CYP2C8, CYP3A4 and P-glycoprotein by rifampin increases paclitaxel clearance.
What to do
Avoid combination where possible and use an alternative antimycobacterial agent; if unavoidable, monitor tumor response closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Paclitaxel
Frequently asked questions
Can I take Paclitaxel with Rifampin?
MediHelp rates the interaction as major. Paclitaxel and Rifampin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rifampin strongly induces CYP2C8, CYP3A4 and P-glycoprotein, which can substantially reduce paclitaxel exposure and may compromise efficacy.
How serious is the interaction between Paclitaxel and Rifampin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combination where possible and use an alternative antimycobacterial agent; if unavoidable, monitor tumor response closely.
What other medicines interact with Paclitaxel?
MediHelp also lists interactions of Paclitaxel with, for example, Adenovirus types 4 and 7 live, Cobicistat, Cyclosporine. The full list is on the Paclitaxel page.
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