Drug interactions
Paclitaxel + Sacubitril / valsartan
Severity: Minor
Paclitaxel and Sacubitril / valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paclitaxel might raise valsartan exposure by inhibiting hepatic uptake, but this is largely theoretical. A clinically meaningful effect has not been well established.
What this interaction means in plain words
Paclitaxel and Sacubitril / valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible inhibition of OATP1B1-mediated hepatic uptake of valsartan; the effect is not well established.
What to do
No dose change is generally needed. Monitor blood pressure and renal function as part of routine care.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Paclitaxel
Frequently asked questions
Can I take Paclitaxel with Sacubitril / valsartan?
MediHelp rates the interaction as minor. Paclitaxel and Sacubitril / valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Paclitaxel might raise valsartan exposure by inhibiting hepatic uptake, but this is largely theoretical. A clinically meaningful effect has not been well established.
How serious is the interaction between Paclitaxel and Sacubitril / valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed. Monitor blood pressure and renal function as part of routine care.
What other medicines interact with Paclitaxel?
MediHelp also lists interactions of Paclitaxel with, for example, Adenovirus types 4 and 7 live, Cobicistat, Cyclosporine. The full list is on the Paclitaxel page.
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