Drug interactions
Paclitaxel + Sulfisoxazole
Severity: Minor
Paclitaxel and Sulfisoxazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfonamides such as sulfisoxazole may inhibit CYP2C8 and could raise paclitaxel levels. Evidence is limited and largely theoretical.
What this interaction means in plain words
Paclitaxel and Sulfisoxazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible CYP2C8 inhibition by sulfisoxazole reduces paclitaxel metabolism.
What to do
Monitor for increased paclitaxel toxicity such as neutropenia and neuropathy during short courses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Paclitaxel
Frequently asked questions
Can I take Paclitaxel with Sulfisoxazole?
MediHelp rates the interaction as minor. Paclitaxel and Sulfisoxazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sulfonamides such as sulfisoxazole may inhibit CYP2C8 and could raise paclitaxel levels. Evidence is limited and largely theoretical.
How serious is the interaction between Paclitaxel and Sulfisoxazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased paclitaxel toxicity such as neutropenia and neuropathy during short courses.
What other medicines interact with Paclitaxel?
MediHelp also lists interactions of Paclitaxel with, for example, Adenovirus types 4 and 7 live, Cobicistat, Cyclosporine. The full list is on the Paclitaxel page.
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