Drug interactions
Paclitaxel + Teniposide
Severity: Moderate
Paclitaxel and Teniposide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are myelosuppressive and share P-glycoprotein handling, so concurrent use can increase hematologic toxicity. Teniposide may also raise paclitaxel exposure.
What this interaction means in plain words
Paclitaxel and Teniposide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive myelosuppression, with possible competition for P-glycoprotein efflux.
What to do
Monitor complete blood counts closely. Adjust doses according to the chemotherapy protocol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paclitaxel
Frequently asked questions
Can I take Paclitaxel with Teniposide?
MediHelp rates the interaction as moderate. Paclitaxel and Teniposide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents are myelosuppressive and share P-glycoprotein handling, so concurrent use can increase hematologic toxicity. Teniposide may also raise paclitaxel exposure.
How serious is the interaction between Paclitaxel and Teniposide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts closely. Adjust doses according to the chemotherapy protocol.
What other medicines interact with Paclitaxel?
MediHelp also lists interactions of Paclitaxel with, for example, Adenovirus types 4 and 7 live, Cobicistat, Cyclosporine. The full list is on the Paclitaxel page.
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