Drug interactions
Paclitaxel protein bound + Quinidine
Severity: Moderate
Paclitaxel protein bound and Quinidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine is a P-glycoprotein inhibitor and may raise paclitaxel exposure. Higher levels could increase neutropenia and neuropathy. The clinical significance is not well characterized.
What this interaction means in plain words
Paclitaxel protein bound and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Quinidine inhibits P-glycoprotein efflux of paclitaxel, which may increase its systemic exposure.
What to do
Monitor blood counts and signs of peripheral neuropathy during co-therapy. Reduce or delay the paclitaxel dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Frequently asked questions
Can I take Paclitaxel protein bound with Quinidine?
MediHelp rates the interaction as moderate. Paclitaxel protein bound and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinidine is a P-glycoprotein inhibitor and may raise paclitaxel exposure. Higher levels could increase neutropenia and neuropathy. The clinical significance is not well characterized.
How serious is the interaction between Paclitaxel protein bound and Quinidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and signs of peripheral neuropathy during co-therapy. Reduce or delay the paclitaxel dose if toxicity develops.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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