Drug interactions
Paclitaxel protein bound + Verapamil
Severity: Moderate
Paclitaxel protein bound and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil inhibits P-glycoprotein, which may increase exposure to paclitaxel and its toxicity, such as neutropenia and neuropathy. Verapamil also inhibits CYP3A4, which contributes to paclitaxel metabolism.
What this interaction means in plain words
Paclitaxel protein bound and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Verapamil inhibits P-gp efflux and CYP3A4 metabolism of paclitaxel.
What to do
Monitor blood counts and signs of neuropathy. Consider an alternative antihypertensive or reduce the paclitaxel dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Paclitaxel protein bound with Verapamil?
MediHelp rates the interaction as moderate. Paclitaxel protein bound and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Verapamil inhibits P-glycoprotein, which may increase exposure to paclitaxel and its toxicity, such as neutropenia and neuropathy. Verapamil also inhibits CYP3A4, which contributes to paclitaxel metabolism.
How serious is the interaction between Paclitaxel protein bound and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and signs of neuropathy. Consider an alternative antihypertensive or reduce the paclitaxel dose if toxicity develops.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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