Drug interactions
Palifermin + Sunitinib
Severity: Moderate
Palifermin and Sunitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Palifermin stimulates epithelial cell growth and is labeled to be kept apart from cytotoxic therapy because mucositis worsened when it was given close to chemotherapy. Its use around sunitinib is not established and could theoretically heighten mucosal toxicity or tumour growth stimulation.
What this interaction means in plain words
Palifermin and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Palifermin belongs to Miscellaneous; Sunitinib belongs to Oncology.
Why it happens
Palifermin stimulates proliferation of epithelial cells, which may increase sensitivity to antineoplastic agents; the specific effect with sunitinib is not well characterized.
What to do
Avoid giving palifermin within 24 hours before or after antineoplastic therapy, as labeled for chemotherapy. Monitor oral mucositis if the combination is used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sunitinib
- Adagrasib + Sunitinib Major
- Amiodarone + Sunitinib Major
- Amisulpride + Sunitinib Major
- Anagrelide + Sunitinib Major
- Apalutamide + Sunitinib Major
- Arsenic trioxide + Sunitinib Major
Other interactions of Palifermin
Frequently asked questions
Can I take Palifermin with Sunitinib?
MediHelp rates the interaction as moderate. Palifermin and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Palifermin stimulates epithelial cell growth and is labeled to be kept apart from cytotoxic therapy because mucositis worsened when it was given close to chemotherapy. Its use around sunitinib is not established and could theoretically heighten mucosal toxicity or tumour growth stimulation.
How serious is the interaction between Palifermin and Sunitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving palifermin within 24 hours before or after antineoplastic therapy, as labeled for chemotherapy. Monitor oral mucositis if the combination is used.
What other medicines interact with Sunitinib?
MediHelp also lists interactions of Sunitinib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sunitinib page.
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