Drug interactions
Palifermin + Tretinoin
Severity: Moderate
Palifermin and Tretinoin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Palifermin given close to antineoplastic therapy may worsen and prolong oral mucositis. Whether this applies to differentiating agents such as tretinoin is uncertain, but the same timing precaution is advised.
What this interaction means in plain words
Palifermin and Tretinoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Palifermin belongs to Miscellaneous; Tretinoin belongs to Dermatology.
Why it happens
Palifermin stimulates epithelial proliferation, which may increase sensitivity to concurrent antineoplastic effects.
What to do
Separate palifermin from antineoplastic therapy by at least 24 hours before and after. Monitor the oral mucosa if overlap is unavoidable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tretinoin
- Doxycycline + Tretinoin Major
- Minocycline + Tretinoin Major
- Omadacycline + Tretinoin Major
- Palovarotene + Tretinoin Major
- Sarecycline + Tretinoin Major
- Tetracycline + Tretinoin Major
Other interactions of Palifermin
Frequently asked questions
Can I take Palifermin with Tretinoin?
MediHelp rates the interaction as moderate. Palifermin and Tretinoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Palifermin given close to antineoplastic therapy may worsen and prolong oral mucositis. Whether this applies to differentiating agents such as tretinoin is uncertain, but the same timing precaution is advised.
How serious is the interaction between Palifermin and Tretinoin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate palifermin from antineoplastic therapy by at least 24 hours before and after. Monitor the oral mucosa if overlap is unavoidable.
What other medicines interact with Tretinoin?
MediHelp also lists interactions of Tretinoin with, for example, Doxycycline, Minocycline, Omadacycline. The full list is on the Tretinoin page.
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