Drug interactions
Palifermin + Vincristine
Severity: Major
Palifermin and Vincristine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Palifermin stimulates epithelial cell growth and when given close to chemotherapy has been associated with more severe and longer-lasting oral mucositis. This may occur with vincristine-containing regimens.
What this interaction means in plain words
Palifermin and Vincristine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Palifermin belongs to Miscellaneous; Vincristine belongs to Oncology.
Why it happens
Palifermin-induced proliferation of epithelial cells may increase their sensitivity to cytotoxic damage when exposure overlaps.
What to do
Do not give palifermin within 24 hours before, during, or within 24 hours after vincristine. Follow labeled timing relative to chemotherapy.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Vincristine
- Adenovirus types 4 and 7 live + Vincristine Contraindicated
- Apalutamide + Vincristine Major
- Atazanavir + Vincristine Major
- Ceritinib + Vincristine Major
- Chloramphenicol + Vincristine Major
- Clarithromycin + Vincristine Major
Other interactions of Palifermin
Frequently asked questions
Can I take Palifermin with Vincristine?
MediHelp rates the interaction as major. Palifermin and Vincristine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Palifermin stimulates epithelial cell growth and when given close to chemotherapy has been associated with more severe and longer-lasting oral mucositis. This may occur with vincristine-containing regimens.
How serious is the interaction between Palifermin and Vincristine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give palifermin within 24 hours before, during, or within 24 hours after vincristine. Follow labeled timing relative to chemotherapy.
What other medicines interact with Vincristine?
MediHelp also lists interactions of Vincristine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vincristine page.
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