Drug interactions
Palifermin + Vinorelbine
Severity: Major
Palifermin and Vinorelbine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Palifermin given close to cytotoxic chemotherapy has been associated with more severe and longer-lasting oral mucositis. This stems from stimulation of epithelial cell proliferation that makes the cells more vulnerable to the chemotherapy.
What this interaction means in plain words
Palifermin and Vinorelbine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Palifermin belongs to Miscellaneous; Vinorelbine belongs to Oncology.
Why it happens
Palifermin stimulates proliferation of epithelial cells, which may increase their susceptibility to cytotoxic damage when given near chemotherapy.
What to do
Do not give palifermin within 24 hours before, during, or within 24 hours after vinorelbine. Space doses according to labeling.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Vinorelbine
Other interactions of Palifermin
Frequently asked questions
Can I take Palifermin with Vinorelbine?
MediHelp rates the interaction as major. Palifermin and Vinorelbine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Palifermin given close to cytotoxic chemotherapy has been associated with more severe and longer-lasting oral mucositis. This stems from stimulation of epithelial cell proliferation that makes the cells more vulnerable to the chemotherapy.
How serious is the interaction between Palifermin and Vinorelbine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give palifermin within 24 hours before, during, or within 24 hours after vinorelbine. Space doses according to labeling.
What other medicines interact with Vinorelbine?
MediHelp also lists interactions of Vinorelbine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Belatacept. The full list is on the Vinorelbine page.
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