Drug interactions
Paliperidone + Pimozide
Severity: Contraindicated
Paliperidone and Pimozide: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs prolong the QT interval, so combined use raises the risk of torsades de pointes. Pimozide labeling cautions against pairing it with other QT-prolonging antipsychotics.
What this interaction means in plain words
Paliperidone and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Paliperidone belongs to Central Nervous System; Pimozide belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Do not co-prescribe; use one antipsychotic. If switching, ensure washout and monitor ECG and electrolytes.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
- Amitriptyline + Paliperidone Major
Frequently asked questions
Can I take Paliperidone with Pimozide?
MediHelp rates the interaction as contraindicated. Paliperidone and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs prolong the QT interval, so combined use raises the risk of torsades de pointes. Pimozide labeling cautions against pairing it with other QT-prolonging antipsychotics.
How serious is the interaction between Paliperidone and Pimozide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-prescribe; use one antipsychotic. If switching, ensure washout and monitor ECG and electrolytes.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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