Drug interactions
Ibutilide + Paliperidone
Severity: Contraindicated
Ibutilide and Paliperidone: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibutilide is a class III antiarrhythmic with a well-known risk of marked QT prolongation and torsades de pointes. Adding paliperidone, which also lengthens QTc, further increases this risk.
What this interaction means in plain words
Ibutilide and Paliperidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ibutilide belongs to Cardiovascular; Paliperidone belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic QT prolongation through potassium channel blockade.
What to do
Avoid using these drugs together. If ibutilide is required for cardioversion, consider holding paliperidone where clinically feasible, and use continuous ECG monitoring with electrolytes corrected.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ibutilide and Paliperidone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Paliperidone
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
- Amitriptyline + Paliperidone Major
Other interactions of Ibutilide
- Amiodarone + Ibutilide Contraindicated
- Amisulpride + Ibutilide Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Clarithromycin + Ibutilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Dolasetron + Ibutilide Contraindicated
Frequently asked questions
Can I take Ibutilide with Paliperidone?
MediHelp rates the interaction as contraindicated. Ibutilide and Paliperidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ibutilide is a class III antiarrhythmic with a well-known risk of marked QT prolongation and torsades de pointes. Adding paliperidone, which also lengthens QTc, further increases this risk.
How serious is the interaction between Ibutilide and Paliperidone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using these drugs together. If ibutilide is required for cardioversion, consider holding paliperidone where clinically feasible, and use continuous ECG monitoring with electrolytes corrected.
What other medicines interact with Paliperidone?
MediHelp also lists interactions of Paliperidone with, for example, Pimozide, Vandetanib, Adagrasib. The full list is on the Paliperidone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
