Drug interactions
Paliperidone + Vandetanib
Severity: Contraindicated
Paliperidone and Vandetanib: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vandetanib markedly prolongs the QT interval and is labeled to be avoided with other QT-prolonging drugs. Adding paliperidone increases the risk of torsades de pointes and sudden death.
What this interaction means in plain words
Paliperidone and Vandetanib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Paliperidone belongs to Central Nervous System; Vandetanib belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation through cardiac potassium channel (hERG) blockade.
What to do
Avoid the combination and choose an alternative antipsychotic with minimal QT effect if possible. If unavoidable, monitor ECG, potassium, magnesium and calcium frequently.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
- Amitriptyline + Paliperidone Major
Other interactions of Vandetanib
- Amiodarone + Vandetanib Contraindicated
- Amisulpride + Vandetanib Contraindicated
- Amitriptyline + Vandetanib Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Asenapine + Vandetanib Contraindicated
- Chloroquine + Vandetanib Contraindicated
Frequently asked questions
Can I take Paliperidone with Vandetanib?
MediHelp rates the interaction as contraindicated. Paliperidone and Vandetanib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Vandetanib markedly prolongs the QT interval and is labeled to be avoided with other QT-prolonging drugs. Adding paliperidone increases the risk of torsades de pointes and sudden death.
How serious is the interaction between Paliperidone and Vandetanib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an alternative antipsychotic with minimal QT effect if possible. If unavoidable, monitor ECG, potassium, magnesium and calcium frequently.
What other medicines interact with Paliperidone?
MediHelp also lists interactions of Paliperidone with, for example, Ibutilide, Pimozide, Adagrasib. The full list is on the Paliperidone page.
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