Drug interactions
Palonosetron + Rasagiline
Severity: Moderate
Palonosetron and Rasagiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rasagiline is a selective MAO-B inhibitor, with limited serotonergic liability at recommended doses. Rare serotonin syndrome reports with 5-HT3 antagonists make awareness reasonable.
What this interaction means in plain words
Palonosetron and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Palonosetron belongs to Gastrointestinal Tract; Rasagiline belongs to Central Nervous System.
Why it happens
Possible additive serotonergic effects; not firmly established.
What to do
Use if needed and monitor for serotonin syndrome symptoms. Stop and treat supportively if they appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Palonosetron
- Apomorphine + Palonosetron Contraindicated
- Isocarboxazid + Palonosetron Major
- Palonosetron + Phenelzine Major
- Palonosetron + Tranylcypromine Major
- Almotriptan + Palonosetron Moderate
- Amitriptyline + Palonosetron Moderate
Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Frequently asked questions
Can I take Palonosetron with Rasagiline?
MediHelp rates the interaction as moderate. Palonosetron and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rasagiline is a selective MAO-B inhibitor, with limited serotonergic liability at recommended doses. Rare serotonin syndrome reports with 5-HT3 antagonists make awareness reasonable.
How serious is the interaction between Palonosetron and Rasagiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use if needed and monitor for serotonin syndrome symptoms. Stop and treat supportively if they appear.
What other medicines interact with Palonosetron?
MediHelp also lists interactions of Palonosetron with, for example, Apomorphine, Isocarboxazid, Phenelzine. The full list is on the Palonosetron page.
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