Drug interactions
Palonosetron + Selegiline
Severity: Moderate
Palonosetron and Selegiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selegiline inhibits MAO-B at low doses but loses selectivity at higher doses or in transdermal use, raising serotonergic risk. Rare serotonin syndrome reports with 5-HT3 antagonists make caution reasonable.
What this interaction means in plain words
Palonosetron and Selegiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Palonosetron belongs to Gastrointestinal Tract; Selegiline belongs to Central Nervous System.
Why it happens
Possible additive serotonergic effects with MAO inhibition; not firmly established.
What to do
Monitor for serotonin syndrome symptoms, especially with higher selegiline doses. Stop and treat supportively if they appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Palonosetron
- Apomorphine + Palonosetron Contraindicated
- Isocarboxazid + Palonosetron Major
- Palonosetron + Phenelzine Major
- Palonosetron + Tranylcypromine Major
- Almotriptan + Palonosetron Moderate
- Amitriptyline + Palonosetron Moderate
Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Frequently asked questions
Can I take Palonosetron with Selegiline?
MediHelp rates the interaction as moderate. Palonosetron and Selegiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selegiline inhibits MAO-B at low doses but loses selectivity at higher doses or in transdermal use, raising serotonergic risk. Rare serotonin syndrome reports with 5-HT3 antagonists make caution reasonable.
How serious is the interaction between Palonosetron and Selegiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for serotonin syndrome symptoms, especially with higher selegiline doses. Stop and treat supportively if they appear.
What other medicines interact with Palonosetron?
MediHelp also lists interactions of Palonosetron with, for example, Apomorphine, Isocarboxazid, Phenelzine. The full list is on the Palonosetron page.
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