Drug interactions
Panax ginseng + Tranylcypromine
Severity: Moderate
Panax ginseng and Tranylcypromine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Panax ginseng has been reported with MAOIs in case reports describing headache, tremor and manic-like excitation. Combining it with tranylcypromine may add to stimulant and adrenergic effects in susceptible patients.
What this interaction means in plain words
Panax ginseng and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible additive central stimulant and sympathomimetic effects; the mechanism is not firmly established.
What to do
Advise patients to avoid ginseng products while on tranylcypromine. If used, monitor for agitation, insomnia, headache and blood pressure rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Panax ginseng with Tranylcypromine?
MediHelp rates the interaction as moderate. Panax ginseng and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Panax ginseng has been reported with MAOIs in case reports describing headache, tremor and manic-like excitation. Combining it with tranylcypromine may add to stimulant and adrenergic effects in susceptible patients.
How serious is the interaction between Panax ginseng and Tranylcypromine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid ginseng products while on tranylcypromine. If used, monitor for agitation, insomnia, headache and blood pressure rises.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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