Drug interactions
Pancuronium + Sufentanil sl
Severity: Moderate
Pancuronium and Sufentanil sl: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sufentanil is an opioid that depresses respiration, and pancuronium paralyzes respiratory muscles, so together they risk hypoventilation if breathing is not supported. They are routinely combined in anesthesia under ventilatory control.
What this interaction means in plain words
Pancuronium and Sufentanil sl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Central opioid respiratory depression adds to neuromuscular blockade of respiratory muscles.
What to do
Use only where airway control and ventilation are available, and titrate to effect. Monitor ventilation and neuromuscular recovery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pancuronium
Frequently asked questions
Can I take Pancuronium with Sufentanil sl?
MediHelp rates the interaction as moderate. Pancuronium and Sufentanil sl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sufentanil is an opioid that depresses respiration, and pancuronium paralyzes respiratory muscles, so together they risk hypoventilation if breathing is not supported. They are routinely combined in anesthesia under ventilatory control.
How serious is the interaction between Pancuronium and Sufentanil sl?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only where airway control and ventilation are available, and titrate to effect. Monitor ventilation and neuromuscular recovery.
What other medicines interact with Pancuronium?
MediHelp also lists interactions of Pancuronium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin. The full list is on the Pancuronium page.
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