Drug interactions
Pantoprazole + Pazopanib
Severity: Moderate
Pantoprazole and Pazopanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pazopanib absorption depends on an acidic gastric environment, and pantoprazole raises gastric pH. This can lower pazopanib exposure and reduce its antitumor efficacy.
What this interaction means in plain words
Pantoprazole and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pantoprazole belongs to Gastrointestinal Tract; Pazopanib belongs to Oncology.
Why it happens
Reduced pazopanib solubility and absorption due to increased gastric pH.
What to do
Avoid the PPI where possible; if acid suppression is required, pazopanib may be taken once daily without food at the same time as the PPI in the evening. Alternatively use a short-acting antacid separated by several hours, and monitor treatment response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Other interactions of Pantoprazole
- Pantoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Pantoprazole Major
- Atazanavir + Pantoprazole Major
- Dacomitinib + Pantoprazole Major
- Dasatinib + Pantoprazole Major
- Erlotinib + Pantoprazole Major
Frequently asked questions
Can I take Pantoprazole with Pazopanib?
MediHelp rates the interaction as moderate. Pantoprazole and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pazopanib absorption depends on an acidic gastric environment, and pantoprazole raises gastric pH. This can lower pazopanib exposure and reduce its antitumor efficacy.
How serious is the interaction between Pantoprazole and Pazopanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the PPI where possible; if acid suppression is required, pazopanib may be taken once daily without food at the same time as the PPI in the evening. Alternatively use a short-acting antacid separated by several hours, and monitor treatment response.
What other medicines interact with Pazopanib?
MediHelp also lists interactions of Pazopanib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pazopanib page.
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