Drug interactions
Paracetamol + Rufinamide
Severity: Minor
Paracetamol and Rufinamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rufinamide is a weak inducer of CYP3A4 and may modestly increase paracetamol metabolism. A clinically important effect on paracetamol exposure or hepatotoxicity is not established.
What this interaction means in plain words
Paracetamol and Rufinamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Paracetamol belongs to Musculoskeletal; Rufinamide belongs to Central Nervous System.
Why it happens
Weak enzyme induction by rufinamide may modestly increase paracetamol metabolism; evidence is limited.
What to do
No dose change is needed for usual paracetamol use. Avoid chronic high doses and check liver tests if prolonged use is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Paracetamol and Rufinamide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Paracetamol
- Ethanol + Paracetamol Major
- Busulfan + Paracetamol Moderate
- Carbamazepine + Paracetamol Moderate
- Cholestyramine + Paracetamol Moderate
- Felbamate + Paracetamol Moderate
- Fosphenytoin + Paracetamol Moderate
Other interactions of Rufinamide
- Carbamazepine + Rufinamide Moderate
- Desogestrel-ethinyl estradiol + Rufinamide Moderate
- Dronedarone + Rufinamide Moderate
- Esketamine + Rufinamide Moderate
- Ethinyl estradiol-drospirenone + Rufinamide Moderate
- Ethinyl estradiol-levonorgestrel + Rufinamide Moderate
Frequently asked questions
Can I take Paracetamol with Rufinamide?
MediHelp rates the interaction as minor. Paracetamol and Rufinamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rufinamide is a weak inducer of CYP3A4 and may modestly increase paracetamol metabolism. A clinically important effect on paracetamol exposure or hepatotoxicity is not established.
How serious is the interaction between Paracetamol and Rufinamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed for usual paracetamol use. Avoid chronic high doses and check liver tests if prolonged use is needed.
What other medicines interact with Paracetamol?
MediHelp also lists interactions of Paracetamol with, for example, Ethanol, Busulfan, Carbamazepine. The full list is on the Paracetamol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
