Drug interactions
Parecoxib + Prednisone
Severity: Moderate
Parecoxib and Prednisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids combined with NSAIDs increase the risk of gastrointestinal ulceration and bleeding. COX-2 selectivity of parecoxib lowers but does not eliminate this risk.
What this interaction means in plain words
Parecoxib and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive gastrointestinal mucosal injury and impaired healing.
What to do
Use the shortest effective parecoxib course and consider a proton pump inhibitor in high-risk patients. Monitor for GI bleeding symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Frequently asked questions
Can I take Parecoxib with Prednisone?
MediHelp rates the interaction as moderate. Parecoxib and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids combined with NSAIDs increase the risk of gastrointestinal ulceration and bleeding. COX-2 selectivity of parecoxib lowers but does not eliminate this risk.
How serious is the interaction between Parecoxib and Prednisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the shortest effective parecoxib course and consider a proton pump inhibitor in high-risk patients. Monitor for GI bleeding symptoms.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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