Drug interactions
Parecoxib + Probenecid
Severity: Minor
Parecoxib and Probenecid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Parecoxib is converted to valdecoxib, an acidic compound that may compete with probenecid for renal tubular secretion. Probenecid can in turn raise valdecoxib exposure. The clinical effect is generally modest but may increase NSAID-related adverse effects.
What this interaction means in plain words
Parecoxib and Probenecid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Probenecid inhibits renal organic anion transporters, reducing tubular secretion of valdecoxib, the active metabolite of parecoxib.
What to do
No routine dose change is needed; watch for signs of increased COX-2 inhibitor effects such as edema, hypertension or renal impairment during prolonged co-use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Frequently asked questions
Can I take Parecoxib with Probenecid?
MediHelp rates the interaction as minor. Parecoxib and Probenecid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Parecoxib is converted to valdecoxib, an acidic compound that may compete with probenecid for renal tubular secretion. Probenecid can in turn raise valdecoxib exposure. The clinical effect is generally modest but may increase NSAID-related adverse effects.
How serious is the interaction between Parecoxib and Probenecid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; watch for signs of increased COX-2 inhibitor effects such as edema, hypertension or renal impairment during prolonged co-use.
What other medicines interact with Probenecid?
MediHelp also lists interactions of Probenecid with, for example, Ketorolac intranasal, Ketorolac, Baricitinib. The full list is on the Probenecid page.
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