Drug interactions
Parecoxib + Secobarbital
Severity: Minor
Parecoxib and Secobarbital: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce hepatic enzymes and may lower exposure to valdecoxib, the active metabolite of parecoxib. This could reduce analgesic or anti-inflammatory effect. The magnitude with secobarbital is not well characterised.
What this interaction means in plain words
Parecoxib and Secobarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Barbiturate-mediated induction of hepatic metabolism (including CYP2C9 and CYP3A4) may increase clearance of valdecoxib.
What to do
Assess analgesic response and increase pain-control measures if effect appears reduced; no routine dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Frequently asked questions
Can I take Parecoxib with Secobarbital?
MediHelp rates the interaction as minor. Parecoxib and Secobarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Barbiturates induce hepatic enzymes and may lower exposure to valdecoxib, the active metabolite of parecoxib. This could reduce analgesic or anti-inflammatory effect. The magnitude with secobarbital is not well characterised.
How serious is the interaction between Parecoxib and Secobarbital?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess analgesic response and increase pain-control measures if effect appears reduced; no routine dose change is needed.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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