Drug interactions
Parecoxib + Tolazamide
Severity: Minor
Parecoxib and Tolazamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may potentiate sulfonylurea hypoglycemia in some cases. Parecoxib is usually used for short perioperative periods, which limits exposure.
What this interaction means in plain words
Parecoxib and Tolazamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible CYP2C9 competition or protein-binding effects; mechanism not well established.
What to do
Monitor blood glucose during parecoxib use, particularly if renal function is reduced or the patient is fasting.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Parecoxib with Tolazamide?
MediHelp rates the interaction as minor. Parecoxib and Tolazamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. NSAIDs may potentiate sulfonylurea hypoglycemia in some cases. Parecoxib is usually used for short perioperative periods, which limits exposure.
How serious is the interaction between Parecoxib and Tolazamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during parecoxib use, particularly if renal function is reduced or the patient is fasting.
What other medicines interact with Tolazamide?
MediHelp also lists interactions of Tolazamide with, for example, Disopyramide, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolazamide page.
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