Drug interactions
Parecoxib + Valproic acid
Severity: Moderate
Parecoxib and Valproic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valproate may modestly inhibit CYP2C9, the enzyme that converts the parecoxib metabolite valdecoxib to inactive products, potentially raising its exposure. NSAIDs can also add to valproate-related bleeding tendencies via platelet effects.
What this interaction means in plain words
Parecoxib and Valproic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Valproate inhibition of CYP2C9 may reduce valdecoxib clearance; additive antiplatelet effects.
What to do
Use the lowest effective parecoxib dose for the shortest time. Monitor for bleeding, renal function and blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Valproic acid
- Ertapenem + Valproic acid Contraindicated
- Imipenem / cilastatin / relebactam + Valproic acid Contraindicated
- Imipenem / cilastatin + Valproic acid Contraindicated
- Meropenem / vaborbactam + Valproic acid Contraindicated
- Meropenem + Valproic acid Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Valproic acid Major
Frequently asked questions
Can I take Parecoxib with Valproic acid?
MediHelp rates the interaction as moderate. Parecoxib and Valproic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valproate may modestly inhibit CYP2C9, the enzyme that converts the parecoxib metabolite valdecoxib to inactive products, potentially raising its exposure. NSAIDs can also add to valproate-related bleeding tendencies via platelet effects.
How serious is the interaction between Parecoxib and Valproic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective parecoxib dose for the shortest time. Monitor for bleeding, renal function and blood pressure.
What other medicines interact with Valproic acid?
MediHelp also lists interactions of Valproic acid with, for example, Ertapenem, Imipenem / cilastatin / relebactam, Imipenem / cilastatin. The full list is on the Valproic acid page.
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