Drug interactions
Parecoxib + Vancomycin
Severity: Moderate
Parecoxib and Vancomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Parecoxib, an NSAID prodrug of valdecoxib, may reduce renal perfusion and vancomycin clearance, potentially raising vancomycin levels and nephrotoxicity risk. Reports concern mainly neonates.
What this interaction means in plain words
Parecoxib and Vancomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID-related inhibition of renal prostaglandins lowers glomerular filtration and vancomycin clearance.
What to do
Monitor serum creatinine and vancomycin troughs, and limit the duration of concurrent use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vancomycin
- Amikacin + Vancomycin Major
- Bacitracin + Vancomycin Major
- Capreomycin + Vancomycin Major
- Cephaloridine + Vancomycin Major
- Cidofovir + Vancomycin Major
- Cisplatin + Vancomycin Major
Frequently asked questions
Can I take Parecoxib with Vancomycin?
MediHelp rates the interaction as moderate. Parecoxib and Vancomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Parecoxib, an NSAID prodrug of valdecoxib, may reduce renal perfusion and vancomycin clearance, potentially raising vancomycin levels and nephrotoxicity risk. Reports concern mainly neonates.
How serious is the interaction between Parecoxib and Vancomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and vancomycin troughs, and limit the duration of concurrent use.
What other medicines interact with Vancomycin?
MediHelp also lists interactions of Vancomycin with, for example, Amikacin, Bacitracin, Capreomycin. The full list is on the Vancomycin page.
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