Drug interactions
Parecoxib + Verapamil
Severity: Minor
Parecoxib and Verapamil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Parecoxib is converted to valdecoxib, which is metabolized by CYP3A4 and CYP2C9, so verapamil may modestly increase valdecoxib exposure. NSAIDs can also blunt the antihypertensive effect of calcium channel blockers.
What this interaction means in plain words
Parecoxib and Verapamil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak CYP3A4 inhibition by verapamil reducing valdecoxib clearance; NSAID-related sodium retention may counter antihypertensive effect.
What to do
Monitor blood pressure and for NSAID adverse effects with prolonged use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Parecoxib with Verapamil?
MediHelp rates the interaction as minor. Parecoxib and Verapamil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Parecoxib is converted to valdecoxib, which is metabolized by CYP3A4 and CYP2C9, so verapamil may modestly increase valdecoxib exposure. NSAIDs can also blunt the antihypertensive effect of calcium channel blockers.
How serious is the interaction between Parecoxib and Verapamil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and for NSAID adverse effects with prolonged use.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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