Drug interactions
Paricalcitol + Phenytoin
Severity: Minor
Paricalcitol and Phenytoin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenytoin induces CYP3A4 and may lower paricalcitol levels. Phenytoin also affects vitamin D metabolism, so the combined effect on mineral control may be reduced.
What this interaction means in plain words
Paricalcitol and Phenytoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Paricalcitol belongs to Musculoskeletal; Phenytoin belongs to Central Nervous System.
Why it happens
Enzyme induction by phenytoin may increase paricalcitol metabolism.
What to do
Monitor serum calcium and parathyroid hormone, and adjust the paricalcitol dose if response is reduced.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Phenytoin
- Artemether / lumefantrine + Phenytoin Contraindicated
- Bictegravir + Phenytoin Contraindicated
- Cabotegravir + Phenytoin Contraindicated
- Doravirine + Phenytoin Contraindicated
- Elbasvir / grazoprevir + Phenytoin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Phenytoin Contraindicated
Other interactions of Paricalcitol
- Carbamazepine + Paricalcitol Moderate
- Cholestyramine + Paricalcitol Moderate
- Clarithromycin + Paricalcitol Moderate
- Digoxin + Paricalcitol Moderate
- Ketoconazole + Paricalcitol Moderate
- Paricalcitol + Posaconazole Moderate
Frequently asked questions
Can I take Paricalcitol with Phenytoin?
MediHelp rates the interaction as minor. Paricalcitol and Phenytoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Phenytoin induces CYP3A4 and may lower paricalcitol levels. Phenytoin also affects vitamin D metabolism, so the combined effect on mineral control may be reduced.
How serious is the interaction between Paricalcitol and Phenytoin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium and parathyroid hormone, and adjust the paricalcitol dose if response is reduced.
What other medicines interact with Phenytoin?
MediHelp also lists interactions of Phenytoin with, for example, Artemether / lumefantrine, Bictegravir, Cabotegravir. The full list is on the Phenytoin page.
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