Drug interactions
Cholestyramine + Paricalcitol
Severity: Moderate
Cholestyramine and Paricalcitol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cholestyramine may reduce absorption of oral paricalcitol, a fat-soluble vitamin D analog, and weaken suppression of parathyroid hormone.
What this interaction means in plain words
Cholestyramine and Paricalcitol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cholestyramine belongs to Cardiovascular; Paricalcitol belongs to Musculoskeletal.
Why it happens
Resin binding and impaired bile-dependent absorption of paricalcitol in the gut.
What to do
Separate paricalcitol from cholestyramine by at least 4 hours. Monitor PTH, calcium and phosphate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cholestyramine
Other interactions of Paricalcitol
- Carbamazepine + Paricalcitol Moderate
- Clarithromycin + Paricalcitol Moderate
- Digoxin + Paricalcitol Moderate
- Ketoconazole + Paricalcitol Moderate
- Paricalcitol + Posaconazole Moderate
- Apalutamide + Paricalcitol Minor
Frequently asked questions
Can I take Cholestyramine with Paricalcitol?
MediHelp rates the interaction as moderate. Cholestyramine and Paricalcitol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cholestyramine may reduce absorption of oral paricalcitol, a fat-soluble vitamin D analog, and weaken suppression of parathyroid hormone.
How serious is the interaction between Cholestyramine and Paricalcitol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate paricalcitol from cholestyramine by at least 4 hours. Monitor PTH, calcium and phosphate.
What other medicines interact with Cholestyramine?
MediHelp also lists interactions of Cholestyramine with, for example, Cholic acid, Deferasirox, Leflunomide. The full list is on the Cholestyramine page.
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