Drug interactions
Digoxin + Paricalcitol
Severity: Moderate
Digoxin and Paricalcitol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vitamin D analogues can cause hypercalcemia, which potentiates digoxin's effects on the myocardium and may precipitate arrhythmias. The risk is highest with excessive paricalcitol dosing or calcium supplements.
What this interaction means in plain words
Digoxin and Paricalcitol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Paricalcitol belongs to Musculoskeletal.
Why it happens
Paricalcitol-induced hypercalcemia increases myocardial sensitivity to digoxin.
What to do
Monitor serum calcium and adjust paricalcitol dose to avoid hypercalcemia; monitor ECG and for digoxin toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Other interactions of Paricalcitol
- Carbamazepine + Paricalcitol Moderate
- Cholestyramine + Paricalcitol Moderate
- Clarithromycin + Paricalcitol Moderate
- Ketoconazole + Paricalcitol Moderate
- Paricalcitol + Posaconazole Moderate
- Apalutamide + Paricalcitol Minor
Frequently asked questions
Can I take Digoxin with Paricalcitol?
MediHelp rates the interaction as moderate. Digoxin and Paricalcitol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vitamin D analogues can cause hypercalcemia, which potentiates digoxin's effects on the myocardium and may precipitate arrhythmias. The risk is highest with excessive paricalcitol dosing or calcium supplements.
How serious is the interaction between Digoxin and Paricalcitol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium and adjust paricalcitol dose to avoid hypercalcemia; monitor ECG and for digoxin toxicity.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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