Drug interactions
paroxetine + tamoxifen
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
↓ endoxifen → reduced efficacy.
Mechanism of action
CYP2D6 inhibition.
Clinical management
Avoid strong CYP2D6 inhibitors; choose venlafaxine, citalopram.
Drug reference
References
Frequently asked questions
Can I take paroxetine with tamoxifen?
The interaction is rated: Major. ↓ endoxifen → reduced efficacy.
How serious is the interaction between paroxetine and tamoxifen?
The interaction is rated: Major. Evidence level: High.
How is the interaction between paroxetine and tamoxifen managed?
Avoid strong CYP2D6 inhibitors; choose venlafaxine, citalopram.
Why do paroxetine and tamoxifen interact?
CYP2D6 inhibition.
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