Drug interactions
Paroxetine + Tolmetin
Severity: Moderate
Paroxetine and Tolmetin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paroxetine impairs platelet aggregation, and with an NSAID the risk of bleeding, especially from the upper gastrointestinal tract, rises appreciably.
What this interaction means in plain words
Paroxetine and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Paroxetine belongs to Central Nervous System; Tolmetin belongs to Musculoskeletal.
Why it happens
SSRI depletion of platelet serotonin adds to NSAID platelet inhibition and gastric mucosal injury.
What to do
Monitor for gastrointestinal bleeding and consider a proton pump inhibitor in high-risk patients. Use an alternative analgesic where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Paroxetine with Tolmetin?
MediHelp rates the interaction as moderate. Paroxetine and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Paroxetine impairs platelet aggregation, and with an NSAID the risk of bleeding, especially from the upper gastrointestinal tract, rises appreciably.
How serious is the interaction between Paroxetine and Tolmetin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for gastrointestinal bleeding and consider a proton pump inhibitor in high-risk patients. Use an alternative analgesic where possible.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Tolmetin page.
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