Drug interactions
Paroxetine + Tolterodine
Severity: Minor
Paroxetine and Tolterodine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paroxetine is a strong CYP2D6 inhibitor and increases tolterodine levels while reducing its active metabolite. Overall active moiety changes little, so the interaction is generally of limited clinical importance.
What this interaction means in plain words
Paroxetine and Tolterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Paroxetine belongs to Central Nervous System; Tolterodine belongs to Genitourinary.
Why it happens
CYP2D6 inhibition by paroxetine reduces tolterodine conversion to 5-hydroxymethyltolterodine, with partial CYP3A4 compensation.
What to do
No routine dose adjustment is needed; watch for anticholinergic effects such as dry mouth and constipation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolterodine
Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Paroxetine with Tolterodine?
MediHelp rates the interaction as minor. Paroxetine and Tolterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Paroxetine is a strong CYP2D6 inhibitor and increases tolterodine levels while reducing its active metabolite. Overall active moiety changes little, so the interaction is generally of limited clinical importance.
How serious is the interaction between Paroxetine and Tolterodine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose adjustment is needed; watch for anticholinergic effects such as dry mouth and constipation.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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