Drug interactions
Paroxetine + Zuranolone
Severity: Moderate
Paroxetine and Zuranolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zuranolone causes somnolence and impaired psychomotor performance, and paroxetine can add sedation and cognitive slowing. Together they may increase impairment, including driving ability.
What this interaction means in plain words
Paroxetine and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Paroxetine belongs to Central Nervous System; Zuranolone belongs to Central Nervous System.
Why it happens
Additive central nervous system depressant effects.
What to do
Consider reducing the zuranolone dose if sedation occurs. Advise patients not to drive or operate machinery for at least 12 hours after each zuranolone dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Other interactions of Zuranolone
- Alprazolam + Zuranolone Major
- Amobarbital + Zuranolone Major
- Apalutamide + Zuranolone Major
- Asenapine + Zuranolone Major
- Brexpiprazole + Zuranolone Major
- Butorphanol + Zuranolone Major
Frequently asked questions
Can I take Paroxetine with Zuranolone?
MediHelp rates the interaction as moderate. Paroxetine and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zuranolone causes somnolence and impaired psychomotor performance, and paroxetine can add sedation and cognitive slowing. Together they may increase impairment, including driving ability.
How serious is the interaction between Paroxetine and Zuranolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the zuranolone dose if sedation occurs. Advise patients not to drive or operate machinery for at least 12 hours after each zuranolone dose.
What other medicines interact with Paroxetine?
MediHelp also lists interactions of Paroxetine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Paroxetine page.
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