Drug interactions
Pau d'arco + Sulindac
Severity: Minor
Pau d'arco and Sulindac: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pau d'arco contains naphthoquinones such as lapachol, which may have anticoagulant effects through interference with vitamin K. With sulindac there is a theoretical increase in bleeding risk.
What this interaction means in plain words
Pau d'arco and Sulindac have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical additive effect on hemostasis; pau d'arco may antagonize vitamin K and sulindac impairs platelet function.
What to do
Advise patients to avoid pau d'arco during sulindac therapy. Monitor for bleeding if both are used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Frequently asked questions
Can I take Pau d'arco with Sulindac?
MediHelp rates the interaction as minor. Pau d'arco and Sulindac have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pau d'arco contains naphthoquinones such as lapachol, which may have anticoagulant effects through interference with vitamin K. With sulindac there is a theoretical increase in bleeding risk.
How serious is the interaction between Pau d'arco and Sulindac?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid pau d'arco during sulindac therapy. Monitor for bleeding if both are used.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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