Drug interactions
Pazopanib + Primidone
Severity: Moderate
Pazopanib and Primidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Primidone, partly metabolized to phenobarbital, may reduce pazopanib levels and its efficacy.
What this interaction means in plain words
Pazopanib and Primidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pazopanib belongs to Oncology; Primidone belongs to Central Nervous System.
Why it happens
Primidone and its phenobarbital metabolite induce CYP3A4, increasing pazopanib metabolism.
What to do
Switch to a non-inducing anticonvulsant where possible. If continued, monitor clinical response to pazopanib.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Other interactions of Primidone
- Lorlatinib + Primidone Contraindicated
- Lurasidone + Primidone Contraindicated
- Primidone + Ranolazine Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Voriconazole Contraindicated
- Abiraterone + Primidone Major
Frequently asked questions
Can I take Pazopanib with Primidone?
MediHelp rates the interaction as moderate. Pazopanib and Primidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Primidone, partly metabolized to phenobarbital, may reduce pazopanib levels and its efficacy.
How serious is the interaction between Pazopanib and Primidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Switch to a non-inducing anticonvulsant where possible. If continued, monitor clinical response to pazopanib.
What other medicines interact with Pazopanib?
MediHelp also lists interactions of Pazopanib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pazopanib page.
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