Drug interactions
Pazopanib + Safinamide
Severity: Moderate
Pazopanib and Safinamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pazopanib is an oral BCRP substrate, and safinamide may inhibit intestinal BCRP, increasing its absorption. Higher pazopanib exposure could increase hepatotoxicity, hypertension and diarrhea.
What this interaction means in plain words
Pazopanib and Safinamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pazopanib belongs to Oncology; Safinamide belongs to Central Nervous System.
Why it happens
Safinamide inhibits intestinal BCRP, raising the oral bioavailability of pazopanib.
What to do
Monitor liver enzymes and blood pressure. Reduce the pazopanib dose if adverse effects develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Safinamide
- Amitriptyline + Safinamide Contraindicated
- Amoxapine + Safinamide Contraindicated
- Amphetamine polistirex + Safinamide Contraindicated
- Clomipramine + Safinamide Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Desipramine + Safinamide Contraindicated
Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Pazopanib with Safinamide?
MediHelp rates the interaction as moderate. Pazopanib and Safinamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pazopanib is an oral BCRP substrate, and safinamide may inhibit intestinal BCRP, increasing its absorption. Higher pazopanib exposure could increase hepatotoxicity, hypertension and diarrhea.
How serious is the interaction between Pazopanib and Safinamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and blood pressure. Reduce the pazopanib dose if adverse effects develop.
What other medicines interact with Safinamide?
MediHelp also lists interactions of Safinamide with, for example, Amitriptyline, Amoxapine, Amphetamine polistirex. The full list is on the Safinamide page.
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