Drug interactions
Pazopanib + Sotorasib
Severity: Moderate
Pazopanib and Sotorasib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotorasib may alter exposure to P-gp and BCRP substrates such as pazopanib. The direction and magnitude of the effect on pazopanib are not well characterized, so efficacy or toxicity could change.
What this interaction means in plain words
Pazopanib and Sotorasib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pazopanib belongs to Oncology; Sotorasib belongs to Oncology.
Why it happens
Sotorasib interacts with P-gp and may also induce CYP3A4, potentially changing pazopanib absorption and clearance; the net effect is uncertain.
What to do
Monitor for loss of efficacy and for pazopanib adverse effects such as hypertension and liver enzyme elevation. Check liver tests regularly and adjust pazopanib per labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Other interactions of Sotorasib
- Amobarbital + Sotorasib Major
- Apalutamide + Sotorasib Major
- Carbamazepine + Sotorasib Major
- Colchicine + Sotorasib Major
- Cyclosporin + Sotorasib Major
- Digoxin + Sotorasib Major
Frequently asked questions
Can I take Pazopanib with Sotorasib?
MediHelp rates the interaction as moderate. Pazopanib and Sotorasib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sotorasib may alter exposure to P-gp and BCRP substrates such as pazopanib. The direction and magnitude of the effect on pazopanib are not well characterized, so efficacy or toxicity could change.
How serious is the interaction between Pazopanib and Sotorasib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of efficacy and for pazopanib adverse effects such as hypertension and liver enzyme elevation. Check liver tests regularly and adjust pazopanib per labeling.
What other medicines interact with Pazopanib?
MediHelp also lists interactions of Pazopanib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pazopanib page.
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