Drug interactions
Pazopanib + Tadalafil
Severity: Minor
Pazopanib and Tadalafil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pazopanib weakly inhibits CYP3A4 and may modestly increase tadalafil exposure. The clinical significance is likely small, though tadalafil adverse effects may be more noticeable.
What this interaction means in plain words
Pazopanib and Tadalafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Pazopanib belongs to Oncology; Tadalafil belongs to Genitourinary.
Why it happens
Weak inhibition of CYP3A4-mediated tadalafil metabolism by pazopanib.
What to do
No routine dose change is needed. Monitor for hypotension and other tadalafil adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tadalafil
- Amyl nitrite + Tadalafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Nitroglycerin po + Tadalafil Contraindicated
- Nitroglycerin rectal + Tadalafil Contraindicated
- Nitroglycerin sublingual + Tadalafil Contraindicated
Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Pazopanib with Tadalafil?
MediHelp rates the interaction as minor. Pazopanib and Tadalafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pazopanib weakly inhibits CYP3A4 and may modestly increase tadalafil exposure. The clinical significance is likely small, though tadalafil adverse effects may be more noticeable.
How serious is the interaction between Pazopanib and Tadalafil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor for hypotension and other tadalafil adverse effects.
What other medicines interact with Tadalafil?
MediHelp also lists interactions of Tadalafil with, for example, Amyl nitrite, Isosorbide dinitrate, Isosorbide mononitrate. The full list is on the Tadalafil page.
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