Drug interactions
Pazopanib + Trastuzumab
Severity: Moderate
Pazopanib and Trastuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have been associated with cardiac dysfunction, so combined use may increase the risk of reduced left ventricular ejection fraction. Pazopanib also causes hypertension that adds to cardiac strain.
What this interaction means in plain words
Pazopanib and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pazopanib belongs to Oncology; Trastuzumab belongs to Oncology.
Why it happens
Additive cardiotoxicity through distinct mechanisms.
What to do
Assess LVEF at baseline and periodically and control blood pressure. Interrupt treatment if cardiac function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Other interactions of Trastuzumab
Frequently asked questions
Can I take Pazopanib with Trastuzumab?
MediHelp rates the interaction as moderate. Pazopanib and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have been associated with cardiac dysfunction, so combined use may increase the risk of reduced left ventricular ejection fraction. Pazopanib also causes hypertension that adds to cardiac strain.
How serious is the interaction between Pazopanib and Trastuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess LVEF at baseline and periodically and control blood pressure. Interrupt treatment if cardiac function declines.
What other medicines interact with Pazopanib?
MediHelp also lists interactions of Pazopanib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pazopanib page.
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