Drug interactions
Pazopanib + Triptorelin
Severity: Moderate
Pazopanib and Triptorelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triptorelin and pazopanib can each prolong the QT interval. Combined use may increase the risk of serious ventricular arrhythmias including torsades de pointes.
What this interaction means in plain words
Pazopanib and Triptorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pazopanib belongs to Oncology; Triptorelin belongs to Endocrine.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Obtain baseline and follow-up ECGs and correct electrolyte disturbances, particularly potassium and magnesium. Interrupt or reduce pazopanib if significant QTc prolongation develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Triptorelin
Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Pazopanib with Triptorelin?
MediHelp rates the interaction as moderate. Pazopanib and Triptorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triptorelin and pazopanib can each prolong the QT interval. Combined use may increase the risk of serious ventricular arrhythmias including torsades de pointes.
How serious is the interaction between Pazopanib and Triptorelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain baseline and follow-up ECGs and correct electrolyte disturbances, particularly potassium and magnesium. Interrupt or reduce pazopanib if significant QTc prolongation develops.
What other medicines interact with Triptorelin?
MediHelp also lists interactions of Triptorelin with, for example, Amisulpride, Arsenic trioxide, Bedaquiline. The full list is on the Triptorelin page.
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