Drug interactions
Pazopanib + Vandetanib
Severity: Major
Pazopanib and Vandetanib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs prolong the QT interval, and vandetanib carries a boxed warning for QT prolongation and torsades de pointes. Combined use may markedly raise arrhythmia risk.
What this interaction means in plain words
Pazopanib and Vandetanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pazopanib belongs to Oncology; Vandetanib belongs to Oncology.
Why it happens
Additive QT prolongation through pharmacodynamic effects.
What to do
Avoid combination. If unavoidable, perform frequent ECGs and maintain normal potassium, magnesium and calcium levels.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Other interactions of Vandetanib
- Amiodarone + Vandetanib Contraindicated
- Amisulpride + Vandetanib Contraindicated
- Amitriptyline + Vandetanib Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Asenapine + Vandetanib Contraindicated
- Chloroquine + Vandetanib Contraindicated
Frequently asked questions
Can I take Pazopanib with Vandetanib?
MediHelp rates the interaction as major. Pazopanib and Vandetanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs prolong the QT interval, and vandetanib carries a boxed warning for QT prolongation and torsades de pointes. Combined use may markedly raise arrhythmia risk.
How serious is the interaction between Pazopanib and Vandetanib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combination. If unavoidable, perform frequent ECGs and maintain normal potassium, magnesium and calcium levels.
What other medicines interact with Pazopanib?
MediHelp also lists interactions of Pazopanib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pazopanib page.
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