Drug interactions
Pemetrexed + Peramivir
Severity: Minor
Pemetrexed and Peramivir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are eliminated by the kidney. Peramivir is a single-dose or short-course antiviral, and pemetrexed may compete for renal elimination or impair renal function, potentially raising exposure to either drug.
What this interaction means in plain words
Pemetrexed and Peramivir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible competition for renal tubular secretion and reduced renal clearance.
What to do
Check renal function before use and adjust the peramivir dose to creatinine clearance. Monitor for pemetrexed toxicity such as myelosuppression.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pemetrexed
Frequently asked questions
Can I take Pemetrexed with Peramivir?
MediHelp rates the interaction as minor. Pemetrexed and Peramivir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs are eliminated by the kidney. Peramivir is a single-dose or short-course antiviral, and pemetrexed may compete for renal elimination or impair renal function, potentially raising exposure to either drug.
How serious is the interaction between Pemetrexed and Peramivir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check renal function before use and adjust the peramivir dose to creatinine clearance. Monitor for pemetrexed toxicity such as myelosuppression.
What other medicines interact with Pemetrexed?
MediHelp also lists interactions of Pemetrexed with, for example, Bacitracin, Brexucabtagene autoleucel, Celecoxib. The full list is on the Pemetrexed page.
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