Drug interactions
Pemetrexed + Tenofovir df
Severity: Moderate
Pemetrexed and Tenofovir df: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pemetrexed is cleared mainly by renal excretion and tenofovir can cause proximal tubular injury. Reduced renal function may increase pemetrexed exposure and its toxicity, including myelosuppression and mucositis.
What this interaction means in plain words
Pemetrexed and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Tenofovir nephrotoxicity and shared tubular secretion pathways may reduce pemetrexed clearance.
What to do
Monitor creatinine clearance before and during each pemetrexed cycle and watch blood counts. Consider an alternative antiretroviral if renal function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pemetrexed
Frequently asked questions
Can I take Pemetrexed with Tenofovir df?
MediHelp rates the interaction as moderate. Pemetrexed and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pemetrexed is cleared mainly by renal excretion and tenofovir can cause proximal tubular injury. Reduced renal function may increase pemetrexed exposure and its toxicity, including myelosuppression and mucositis.
How serious is the interaction between Pemetrexed and Tenofovir df?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor creatinine clearance before and during each pemetrexed cycle and watch blood counts. Consider an alternative antiretroviral if renal function declines.
What other medicines interact with Pemetrexed?
MediHelp also lists interactions of Pemetrexed with, for example, Bacitracin, Brexucabtagene autoleucel, Celecoxib. The full list is on the Pemetrexed page.
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