Drug interactions
Pemetrexed + Tenofovir disoproxil
Severity: Moderate
Pemetrexed and Tenofovir disoproxil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pemetrexed depends on renal elimination and is toxic when renal function falls. Tenofovir can cause tubular injury, so combined use may reduce pemetrexed clearance and increase myelosuppression and mucositis, while pemetrexed-related renal injury may raise tenofovir exposure.
What this interaction means in plain words
Pemetrexed and Tenofovir disoproxil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive nephrotoxicity and competition for renal tubular secretion.
What to do
Monitor creatinine clearance before each pemetrexed cycle and watch blood counts. Consider an alternative antiretroviral if renal function deteriorates.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pemetrexed
Frequently asked questions
Can I take Pemetrexed with Tenofovir disoproxil?
MediHelp rates the interaction as moderate. Pemetrexed and Tenofovir disoproxil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pemetrexed depends on renal elimination and is toxic when renal function falls. Tenofovir can cause tubular injury, so combined use may reduce pemetrexed clearance and increase myelosuppression and mucositis, while pemetrexed-related renal injury may raise tenofovir exposure.
How serious is the interaction between Pemetrexed and Tenofovir disoproxil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor creatinine clearance before each pemetrexed cycle and watch blood counts. Consider an alternative antiretroviral if renal function deteriorates.
What other medicines interact with Pemetrexed?
MediHelp also lists interactions of Pemetrexed with, for example, Bacitracin, Brexucabtagene autoleucel, Celecoxib. The full list is on the Pemetrexed page.
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