Drug interactions
Penbutolol + Sulindac
Severity: Moderate
Penbutolol and Sulindac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as sulindac can blunt the blood pressure lowering effect of beta-blockers. The effect is most relevant with regular use over more than a few days.
What this interaction means in plain words
Penbutolol and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of renal and vascular prostaglandin synthesis causes sodium and water retention and reduces vasodilation, opposing the antihypertensive effect.
What to do
Monitor blood pressure when sulindac is started, stopped or changed in dose. Adjust antihypertensive therapy or use the shortest effective NSAID course.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Frequently asked questions
Can I take Penbutolol with Sulindac?
MediHelp rates the interaction as moderate. Penbutolol and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as sulindac can blunt the blood pressure lowering effect of beta-blockers. The effect is most relevant with regular use over more than a few days.
How serious is the interaction between Penbutolol and Sulindac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when sulindac is started, stopped or changed in dose. Adjust antihypertensive therapy or use the shortest effective NSAID course.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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