Drug interactions
Penbutolol + Umeclidinium-vilanterol
Severity: Major
Penbutolol and Umeclidinium-vilanterol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Penbutolol is a nonselective beta-blocker that opposes the bronchodilating effect of vilanterol and can provoke bronchospasm, especially in patients with asthma or COPD. This may reduce the efficacy of the inhaler and worsen airway obstruction.
What this interaction means in plain words
Penbutolol and Umeclidinium-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Pharmacodynamic antagonism at beta-2 adrenergic receptors by a nonselective beta-blocker.
What to do
Avoid nonselective beta-blockers in patients with reactive airway disease and use a cardioselective agent such as bisoprolol or metoprolol if a beta-blocker is needed. Monitor respiratory symptoms and lung function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Umeclidinium-vilanterol
Frequently asked questions
Can I take Penbutolol with Umeclidinium-vilanterol?
MediHelp rates the interaction as major. Penbutolol and Umeclidinium-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Penbutolol is a nonselective beta-blocker that opposes the bronchodilating effect of vilanterol and can provoke bronchospasm, especially in patients with asthma or COPD. This may reduce the efficacy of the inhaler and worsen airway obstruction.
How serious is the interaction between Penbutolol and Umeclidinium-vilanterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid nonselective beta-blockers in patients with reactive airway disease and use a cardioselective agent such as bisoprolol or metoprolol if a beta-blocker is needed. Monitor respiratory symptoms and lung function.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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